/leibniz-lib.de/_assets/639468b5d67b471e16952a11b4231513/Standard/Images/LIB/person.svg%3F1722434549)
Internationale Kooperationen
- Research Associate, Field Museum of Natural History, Chicago, USA
- Research Associate, Natural History Museum, London, Vereinigtes Königreich
- Internationale wissenschaftliche Kooperationen in Phylogenomik, Systematik und Biodiversittsforschung
Wissenschaftliche Kernkompetenzen
Methodenentwicklung
Entwicklung von auf Quartetten basierenden Ansätzen zur Bewertung phylogenetischer Signale und zur Identifizierung systematischer Verzerrungen in phylogenomischen Datensätzen.
Diagnostik phylogenomischer Datensätze
Entwicklung von Analyse-Tools zur Erkennung heterogener Sequenzabweichungen und problematischer phylogenetischer Signale, darunter fallen Tools wie AliGROOVE und verwandte Ansätze.
Computational Workflows
Implementierung automatisierter Pipelines, die phylogenetische Rekonstruktion, Quartettanalysen und Visualisierung unter Verwendung von Perl, Python und R integrieren.
Software
SeaLion
Polarized quartet-based framework for assessing phylogenetic signal, conflict, and systematic bias in genomic datasets; NAR Genomics Bioinf. (2025).
PENGUIN
Perl-based software for quartet site-pattern analyses of aligned nucleotide and amino acid sequences; Cladistics (2017).
AliGROOVE
Tool for visualizing heterogeneous sequence divergence and identifying derived sequences that may bias phylogenetic inference; BMC Bioinformatics (2014).
BaCoCa
Base composition calculator for statistical analyses of sequence alignments and detection of phylogenetic bias; Mol. Phylogenet. Evol. (2014).
FASconCAT-G
Software for editing, processing, and concatenating nucleotide, amino acid, and G structure alignments; Front. Zool. (2014).
AMARE
Software for optimizing signal-to-noise ratios in AFLP datasets by detecting erroneous genotyping profiles; PLoS ONE (2012).
AliCUT
Companion tool for Aliscore to remove random-similarity positions from multiple sequence alignments.
Sämtliche software Tools sind auf meiner GitHub Seite verfügbar.
Projekte
/leibniz-lib.de/fileadmin/user_upload/home/Bilder/LIB/Projekte/Logos/SeaLion_logo_combined_black_bg_with_subtitle.png%3F1775122608)
SeaLion – polarisierte Quartettanalyse in der Phylogenomik
Leitung: Dr. Patrick Kück
Publikationen
| von
2026/02
Clarifying Xenacoelomorpha phylogeny: A polarized quartet-based analysis with SeaLion
Gene
2025/05
Type genomics: a framework for integrating genomic data into biodiversity and taxonomic research
Systematic Biology, 6, 74
2025/03
Unraveling myriapod evolution: sealion, a novel quartet-based approach for evaluating phylogenetic uncertainty
NAR Genomics and Bioinformatics, 1, 7
2022/07
Pitfalls of the site-concordance factor (sCF) as measure of phylogenetic branch support
NAR Genomics and Bioinformatics, 3, 4
2022/05
SHERLOCK – an Automatized Analysis of Molecular Sequence Variation in Species Communities Using Statistical Tests on Patristic Tree Distances
Biodiversity online journal., 4, 2
2017/08
Can quartet analyses combining maximum likelihood estimation and Hennigian logic overcome long branch attraction in phylogenomic sequence data?
PloS one, 8, 12
2016/08
Plesiomorphic character states cause systematic errors in molecular phylogenetic analyses: a simulation study
Cladistics, 4, 32
2014/12
Phylogenetic evidence for multiple independent origins of functional kleptoplasty in Sacoglossa (Heterobranchia, Gastropoda)
Organisms diversity & evolution, 1, 15
2014/11
FASconCAT-G: extensive functions for multiple sequence alignment preparations concerning phylogenetic studies
Frontiers in zoology, 1, 11
2014/08
AliGROOVE – visualization of heterogeneous sequence divergence within multiple sequence alignments and detection of inflated branch support
BMC bioinformatics, 1, 15
2014/04
Platyzoan Paraphyly Based on Phylogenomic Data Supports a Noncoelomate Ancestry of Spiralia
Molecular biology and evolution, 7, 31
2014/01
BaCoCa – A heuristic software tool for the parallel assessment of sequence biases in hundreds of gene and taxon partitions
Molecular phylogenetics and evolution, 70
2013/12
Selecting informative subsets of sparse supermatrices increases the chance to find correct trees
BMC bioinformatics, 1, 14
2012/11
Automated Masking of AFLP Markers Improves Reliability of Phylogenetic Analyses
PloS one, 11, 7
2012/05
Long Branch Effects Distort Maximum Likelihood Phylogenies in Simulations Despite Selection of the Correct Model
PloS one, 5, 7
2011/06
Improved Phylogenetic Analyses Corroborate a Plausible Position of Martialis heureka in the Ant Tree of Life
PloS one, 6, 6
2010/09
FASconCAT: Convenient handling of data matrices
Molecular phylogenetics and evolution, 3, 56
2010/06
The Impact of rRNA Secondary Structure Consideration in Alignment and Tree Reconstruction: Simulated Data and a Case Study on the Phylogeny of Hexapods
Molecular biology and evolution, 11, 27
2010/06
A Phylogenomic Approach to Resolve the Arthropod Tree of Life
Molecular biology and evolution, 11, 27
2010/01
Parametric and non-parametric masking of randomness in sequence alignments can be improved and leads to better resolved trees
Frontiers in zoology, 1, 7