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Dr. Patrick Kück

  • Scientists

Raiffeisenhaus
Adenauerallee 127
53113 Bonn

Phone: +49 228 9122 404
E-Mail: p.kueck@leibniz-lib.de

Researchprofile

I am a computational evolutionary biologist working at the interface of phylogenomics, methodological development, and biodiversity research. My research focuses on identifying when genomic data provide reliable molecular phylogenetic signal and when they are dominated by conflict, noise, or systematic bias.


A central objective of my work is to disentangle genuine evolutionary processes, such as incomplete lineage sorting and introgression, from misleading signal arising from model violations, compositional heterogeneity, or long-branch effects. Rather than assuming that larger datasets necessarily resolve evolutionary relationships, my research explicitly tests the limits of phylogenetic inference in genome-scale data.

To address these challenges, I develop quartet-based analytical frameworks, most notably SeaLion, which evaluate phylogenetic signal at a fine-grained level and quantify both support and conflict across taxa and datasets. This approach allows the identification of misleading signal and provides a diagnostic perspective on phylogenetic reconstruction.


My research integrates methodological development with empirical studies on major evolutionary radiations, including Palaeognathae, Xenacoelomorpha, and Myriapoda. These studies demonstrate that even large genomic datasets can retain persistent and structured conflict, highlighting fundamental limits of resolution and the need for approaches that explicitly account for uncertainty.

Research interests

  • Phylogenomics and deep evolutionary relationships
  • Phylogenetic signal, conflict, and uncertainty
  • Systematic error in molecular phylogenetics
  • Incomplete lineage sorting and introgression
  • Quartet-based inference and methodological development
  • Data quality assessment in genomic datasets
  • Evolutionary relationships within major metazoan lineages

 

International affiliations and cooperations

  • Research Associate, Field Museum of Natural History, Chicago, USA
  • Research Associate, Natural History Museum, London, United Kingdom
  • International scientific collaborations in phylogenomics, systematics and biodiversity research

 

Key Scientific Contributions

  • Method Development

    Development of quartet-based approaches for assessing phylogenetic signal and identifying systematic bias in phylogenomic datasets.

  • Phylogenomic Diagnostics

    Development of analytical tools for detecting heterogeneous sequence divergence and problematic phylogenetic signal, including AliGROOVE and related approaches.

  • Computational Workflows

    Implementation of automated pipelines integrating phylogenetic reconstruction, quartet analyses, and visualization using Perl, Python, and R.

Software

  • SeaLion

    Polarised quartet-based framework for assessing phylogenetic signal, conflict, and systematic bias in genomic datasets; NAR Genomics Bioinf. (2025).

  • PENGUIN

    Perl-based software for quartet site-pattern analyses of aligned nucleotide and amino acid sequences; Cladistics (2017).

  • AliGROOVE

    Tool for visualising heterogeneous sequence divergence and identifying derived sequences that may bias phylogenetic inference; BMC Bioinformatics (2014).

  • BaCoCa

    Base composition calculator for statistical analyses of sequence alignments and detection of phylogenetic bias; Mol. Phylogenet. Evol. (2014).

  • FASconCAT-G

    Software for editing, processing, and concatenating nucleotide, amino acid, and G structure alignments; Front. Zool. (2014).

  • AMARE

    Software for optimising signal-to-noise ratios in AFLP datasets by detecting erroneous genotyping profiles; PLoS ONE (2012).

  • AliCUT

    Companion tool for Aliscore to remove random-similarity positions from multiple sequence alignments.

All software tools are available on my GitHub page.

 

Projects

Publications

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    2026

  • 2026/02

    Kück, P., Wilkinson, M.

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    Clarifying Xenacoelomorpha phylogeny: A polarized quartet-based analysis with SeaLion

    Gene

  • 2025

  • 2025/05

    Letsch, H., Greve, C., Hundsdoerfer, A.K., Irisarri, I., Moore, J.M., Espeland, M., Wanke, S., Arifin, U., Blom, M.P.K., Corrales, C., Donath, A., Fritz, U., Köhler, G., Kück, P., Lemer, S., Mengual, X., Salas, N.M., Meusemann, K., Palandačić, A., Printzen, C., Sigwart, J.D., Silva-Brandão, K.L., Simões, M., Stange, M., Suh, A., Szucsich, N., Tilic, E., Töpfer, T., Böhne, A., Janke, A., Pauls, S.

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    Type genomics: a framework for integrating genomic data into biodiversity and taxonomic research

    Systematic Biology, 6, 74

  • 2025/03

    Kück, P., Wilkinson, M., Romahn, J., Seidel, N., Meusemann, K., Wägele, J.

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    Unraveling myriapod evolution: sealion, a novel quartet-based approach for evaluating phylogenetic uncertainty

    NAR Genomics and Bioinformatics, 1, 7

  • 2022

  • 2022/07

    Kück, P., Romahn, J., Meusemann, K.

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    Pitfalls of the site-concordance factor (sCF) as measure of phylogenetic branch support

    NAR Genomics and Bioinformatics, 3, 4

  • 2022/05

    Seidel, N., Geiger, M., Kück, P.

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    SHERLOCK – an Automatized Analysis of Molecular Sequence Variation in Species Communities Using Statistical Tests on Patristic Tree Distances

    Biodiversity online journal., 4, 2

  • 2017

  • 2017/08

    Kück, P., Wilkinson, M., Groß, C., Foster, P.G., Wägele, J.W.

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    Can quartet analyses combining maximum likelihood estimation and Hennigian logic overcome long branch attraction in phylogenomic sequence data?

    PloS one, 8, 12

  • 2016

  • 2016/08

    Plesiomorphic character states cause systematic errors in molecular phylogenetic analyses: a simulation study

    Cladistics, 4, 32

  • 2014

  • 2014/12

    Christa, G., Händeler, K., Kück, P., Vleugels, M., Franken, J., Karmeinski, D., Wägele, H.

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    Phylogenetic evidence for multiple independent origins of functional kleptoplasty in Sacoglossa (Heterobranchia, Gastropoda)

    Organisms diversity & evolution, 1, 15

  • 2014/11

    Kück, P., Longo, G.C.

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    FASconCAT-G: extensive functions for multiple sequence alignment preparations concerning phylogenetic studies

    Frontiers in zoology, 1, 11

  • 2014/08

    Kück, P., Meid, S., Groß, C., Wägele, J., Misof, B.

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    AliGROOVE – visualization of heterogeneous sequence divergence within multiple sequence alignments and detection of inflated branch support

    BMC bioinformatics, 1, 15

  • 2014/04

    Struck, T.H., Wey-Fabrizius, A.R., Golombek, A., Hering, L., Weigert, A., Bleidorn, C., Klebow, S., Iakovenko, N., Hausdorf, B., Petersen, M., Kück, P., Herlyn, H., Hankeln, T.

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    Platyzoan Paraphyly Based on Phylogenomic Data Supports a Noncoelomate Ancestry of Spiralia

    Molecular biology and evolution, 7, 31

  • 2014/01

    Kück, P., Struck, T.H.

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    BaCoCa – A heuristic software tool for the parallel assessment of sequence biases in hundreds of gene and taxon partitions

    Molecular phylogenetics and evolution, 70

  • 2013

  • 2013/12

    Misof, B., Meyer, B., von Reumont, B.M., Kück, P., Misof, K., Meusemann, K.

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    Selecting informative subsets of sparse supermatrices increases the chance to find correct trees

    BMC bioinformatics, 1, 14

  • 2012

  • 2012/11

    Kück, P., Greve, C., Misof, B., Gimnich, F.

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    Automated Masking of AFLP Markers Improves Reliability of Phylogenetic Analyses

    PloS one, 11, 7

  • 2012/05

    Long Branch Effects Distort Maximum Likelihood Phylogenies in Simulations Despite Selection of the Correct Model

    PloS one, 5, 7

  • 2011

  • 2011/06

    Kück, P., Garcia, F.H., Misof, B., Meusemann, K.

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    Improved Phylogenetic Analyses Corroborate a Plausible Position of Martialis heureka in the Ant Tree of Life

    PloS one, 6, 6

  • 2010

  • 2010/09

    FASconCAT: Convenient handling of data matrices

    Molecular phylogenetics and evolution, 3, 56

  • 2010/06

    Letsch, H., Kück, P., Stocsits, R.R., Misof, B.

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    The Impact of rRNA Secondary Structure Consideration in Alignment and Tree Reconstruction: Simulated Data and a Case Study on the Phylogeny of Hexapods

    Molecular biology and evolution, 11, 27

  • 2010/06

    Meusemann, K., von Reumont, B.M., Simon, S., Roeding, F., Strauss, S.H., Kück, P., Ebersberger, I., Walzl, M., Pass, G., Breuers, S., Achter, V., von Haeseler, A., Burmester, T., Hadrys, H., Wägele, J., Misof, B.

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    A Phylogenomic Approach to Resolve the Arthropod Tree of Life

    Molecular biology and evolution, 11, 27

  • 2010/01

    Kück, P., Meusemann, K., Dambach, J., Thormann, B., von Reumont, B.M., Wägele, J., Misof, B.

    Show more...

    Parametric and non-parametric masking of randomness in sequence alignments can be improved and leads to better resolved trees

    Frontiers in zoology, 1, 7

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